Therapeutic action
- Analgesic, antipyretic, non steroidal anti-inflammatory (NSAID)
- Platelet antiaggregant (at low dose)
Indications
- Mild pain, fever
- Secondary prevention of severe pre-eclampsia
Forms and strengths
- 300 mg tablet
- 75 mg enteric coated tablet
Dosage and duration
Pain and fever
Adolescent over 16 years and adult: 300 mg to 1 g every 4 to 6 hours (max. 4 gdaily), for 1 to 3 days
Prevention of pre-eclampsia:
75 to 150 mg once daily from the 12thto the 36th week of gestation. Stop treatment 5 to 10 days before the expected date of delivery.
Contra-indications, adverse effects, precautions
- Do not administer to patients with allergy to aspirin and NSAID, gastroduodenal ulcer, coagulation disorders, haemorrhage, severe renal, hepatic or cardiac impairment.
- Do not administer to children for pain or fever (use paracetamol).
- Administer with caution to older patients or patients with asthma.
- Do not exceed indicated doses, particularly in older patients. Intoxications are severe, possibly fatal
- May cause:
- allergic reactions, epigastric pain, gastroduodenal ulcer, haemorrhage;
- dizziness, tinnitus(early signs of overdose);
- Reye’s syndrome in children(encephalopathy and severe hepatic disorders).
- For all cases above, stop aspirin.
- Do not combine with methotrexate, anticoagulants or NSAID.
- Monitor combination with insulin(increased hypoglycaemia) and corticosteroids.
- Pregnancy:
- pain and fever: avoid. CONTRA-INDICATED from the beginning of the 6th month. Use paracetamol.
- prevention of pre-eclampsia: do not exceed 150 mg daily.
- Breast-feeding: avoid. Use paracetamol.
Remarks
Take during meals, preferably with a lot of water. Do not crush enteric coated tablets.
Aspirin may be administered in secondary prevention of atherothrombosis, at a dose of 75 to 300 mg daily.
Also comes in 500 mg tablets and 300 mg dispersible tablets.
Storage
– Below 25 °C
Do not use if tablets have a strong smell of vinegar. A slight vinegar smell is always present.