Hypertension, treatment of chronic stable angina pectoris
Chronic stable heart failure in combination with a converting enzyme inhibitor (enalapril)
Forms and strengths
2.5 mg breakable tablet
10 mg breakable in ¼ tablet
Dosage
Hypertension, angina pectoris
Adult: 5 to 10 mg once daily, preferably in the morning (max. 20 mg daily) In patients with renal or hepatic impairment: start with 2.5 mg once daily then increase, if necessary, according to clinical response(max. 10 mg daily)
Heart failure
Adult: start with 1.25 mg once daily and increase according to the table below, as long as the drug is well tolerated (heart rate, blood pressure, signs of worsening heart failure)
Weeks
Daily dose
Tablet(s)
Week 1
1.25 mg once daily
2.5mg tab: ½ tab daily
Week 2
2.5 mg once daily
2.5 mg tab: 1 tab dailyor
10 mg tab: ¼ tab daily
Week 3
3.75 mg once daily
2.5mg tab: 1½ tab daily
Week 4 to 8
5 mg once daily
10mg tab: ½ tab daily
Week 9 to 12
7.5 mg once daily
2.5 mg tab: 1 tab daily+ 10 mg tab: ½ tab dailyor
10 mg tab: ¾ tab daily
From week 13
10 mg once daily (max.10 mg daily)
10 mg tab: 1 tab daily
Duration
According to clinical response. Do not stop treatment abruptly, decrease doses gradually.
Contra-indications, adverse effects, precautions
Do not administer to patients with asthma, chronic obstructive bronchopneumonia, acute heart failure, severe hypotension, bradycardia < 50/minute, atrio-ventricular heart blocks, Raynaud's syndrome.
May cause:
bradycardia, hypotension, worsening of heart failure (reduce dose);
bronchospasm in patients with an obstructive respiratory disease;