Etonogestral subdermal implant

Generic Name: etonogestrel implant

Brand Names:

Availability: Available with Prescription

Drug Class: Hormonal contraceptive

Therapeutic action

  • Hormonal contraceptive, progestogen

Indications

  • Long-acting contraception

Forms and strengths, route of administration

  • Flexible rod containing 68 mg of etonogestrel, in a sterile disposable applicator, to be inserted subdermally into the inner side of the non-dominant arm, 6 to8 cm above the elbow crease, under local anaesthesia and aseptic conditions

Dosage

  • The implant may be inserted at any moment of the cycle if it is reasonably certain the woman is not pregnant, including when switching from another form of contraception.
  • Use condoms for 7 days after insertion of the implant if it is inserted: 
    • more than 7 days after the start of menstruation;
    • more than 28 days postpartum if not breastfeeding; 
    • more than 7 days after an abortion.

Duration

  • As long as this method of contraception is desired and it is well tolerated, for max. 3 years after which it no longer provides contraception and must be changed.

Contra-indications, adverse effects, precautions

  • Do not administer to patients with breast cancer,severe or recent liver disease,unexplained vaginal bleeding, active thromboembolic disorders.
  • May cause: menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness, headache, weight gain, itching, acne, mood changes, abdominal pain, gastrointestinal disturbances, allergic reactions.
  • Enzyme-inducing drugs (rifampicin, rifabutin, efavirenz, nevirapine, lopinavir, ritonavir, phenobarbital, phenytoin, carbamazepine, griseofulvin, etc.) reduce the effectiveness of the contraceptive.
  • Pregnancy: CONTRA-INDICATED
  • Breast-feeding: no contra-indication

Remarks

  • Fertility returns rapidly after removal of the implant.
  • For the conditions for insertion or removal the implant, follow manufacturer’s instructions.

Storage

– Below 25 °C