Therapeutic action
Indications
- Abnormal uterine bleeding (especially functional uterine bleeding unrelated to pregnancy)
Forms and strengths
Dosage and duration
Persistent abnormal uterine bleeding despite tranexamic acid therapy or heavy bleeding when tranexamic acid is contra-indicated
- Adolescent and adult: 20 mg 3 times daily for 7 days
Long-term treatment of functional uterine bleeding
- Adult: 10 mg once daily (up to 30 mg once daily if necessary). Continue treatment according to clinical response.
Contra-indications, adverse effects, precautions
- Do not administer to patients with breast cancer, severe hypertension (≥ 160/100), active thromboembolic disorders, uncontrolled or complicated diabetes, severe or recent hepatic disease.
- May cause: menstrual irregularities, amenorrhoea, menometrorrhagia, breast tenderness, headache, weight gain, acne, mood change, abdominal pain, gastrointestinal disturbances.
- Pregnancy: CONTRA-INDICATED
- Breast-feeding: no contra-indication
Remarks
- Unlike injectable medroxyprogesterone, the oral form has no contraceptive effect.
Storage
– Below 25 °C