Metoclopramide Injectable

Generic Name: Mtoclopramide

Brand Names:

Availability: Available with Prescription

Drug Class: Antiemetic Agents

Therapeutic action

  • Antiemetic (dopamine antagonist)

Indications

  • Prevention or symptomatic treatment of nausea and vomiting in adults

Forms and strengths, route of administration

  • 10 mg in 2 ml ampoule (5 mg/ml) forIM or slow IV injection(3 to 5 minutes)

Dosage

  • Adult: 10 mg every 8 hours if necessary

Duration

  • Change to oral treatment as soon as possible.

Contra-indications, adverse effects, precautions

  • Do not administer to children < 18 years or to patients with gastrointestinal haemorrhage, obstruction or perforation.
  • Reduce the dose by half in patients with severe renal impairment.
  • Administer with caution and monitor use in patients > 60 years and patients with epilepsy or Parkinson's disease.
  • May cause: drowsiness, dizziness, confusion, extrapyramidal symptoms,seizures (especially in patients with epilepsy), allergic reactions, cardiac disorders (hypotension, bradycardia, cardiac arrest); neuroleptic malignant syndrome (unexplained hyperthermia with neuromuscular disorders), rare but requiring immediate treatment discontinuation.
  • Do not combine with levodopa (antagonism).
  • Avoid combination with CNS depressants (opioid analgesics, antipsychotics, sedatives,antidepressants, antihistamines, etc.) and antihypertensive drugs (increased risk of hypotension). 
  • Pregnancy: no contra-indication
  • Breast-feeding: no contra-indication

Remarks

  • For postoperative nausea and vomiting in adults, efficacy of metoclopramide is limited: ondansetron is preferred.

Storage

– Below 25 °C